Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Epithalon 10MG

Epithalon

Epithalon (also known as Epitalon) is a synthetic tetrapeptide composed of the amino acid sequence Ala–Glu–Asp–Gly, developed as a research analog of epithalamic peptides originally isolated from the pineal gland. In scientific research settings, Epithalon is utilized as a peptide research tool for investigating cellular aging processes, telomere biology, circadian signaling, and peptide-mediated regulation of gene expression in controlled experimental models.*

Epithalon is widely referenced in gerontology, molecular biology, and cell signaling research for its role in studying telomerase activity, chromosomal stability, and age-associated cellular mechanisms. Its short, well-defined structure and chemical stability make it a valuable compound for mechanistic studies involving peptide–DNA interactions and intracellular regulatory pathways.*

  • Peptide Name: Epithalon (Epitalon)
  • Peptide Class: Synthetic epithalamic tetrapeptide
  • Amino Acid Length: 4 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)
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Products will arrive in a lyophilized (powder) form for maximum stability.

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Epithalon

Scientific & Research Context

In published scientific literature, Epithalon has been studied in experimental models related to cellular aging, including investigations into telomerase activation, telomere length regulation, and chromosomal stability in somatic cells.* Research has also examined Epithalon’s involvement in circadian rhythm regulation, pineal signaling pathways, and peptide-mediated modulation of gene transcription associated with longevity and cellular homeostasis.*

Within laboratory research environments, Epithalon has been utilized to investigate:*

  • Telomerase activity and telomere length regulation in cell culture systems
  • Mechanisms of cellular aging and replicative senescence
  • Epigenetic regulation and gene expression linked to longevity pathways
  • Circadian rhythm signaling and pineal-derived peptide activity
  • Structure–function relationships of short regulatory peptides

Its minimal amino acid sequence, reproducible synthesis, and well-documented research background make Epithalon a commonly selected compound in aging research, molecular genetics, and peptide biology studies.*

Quality & Analytical Assurance

Each batch of Epithalon is synthesized using validated solid-phase peptide synthesis methods and undergoes rigorous analytical testing to confirm molecular identity, sequence accuracy, and purity. Verification through high-performance liquid chromatography (HPLC) and mass spectrometry (MS) ensures batch-to-batch consistency, reliability, and reproducibility for research applications.

Storage & Handling

Epithalon is supplied as a lyophilized powder to enhance stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established laboratory peptide best practices to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • V. N. Anisimov et al., “The peptide bioregulator Epitalon increases lifespan and inhibits spontaneous tumor development in female mice,” Neuroendocrinol. Lett., vol. 24, no. 6, pp. 455–460, 2003.
  • V. N. Anisimov, S. V. Mylnikov, and V. K. Khavinson, “Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,” Mech. Ageing Dev., vol. 103, no. 2, pp. 123–132, 1998.
  • V. K. Khavinson, I. E. Bondarev, and A. A. Butyugov, “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells,” Bull. Exp. Biol. Med., vol. 135, no. 6, pp. 590–592, 2003.
  • V. Khavinson, A. M. Bondarev, and N. V. Grigoriev, “Effect of pineal peptide Epitalon on telomerase activity in human somatic cells,” Bull. Exp. Biol. Med., vol. 144, no. 3, pp. 394–397, 2007.
  • V. N. Anisimov et al., “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,” Biogerontology, vol. 4, no. 4, pp. 193–202, 2003.
  • V. N. Anisimov et al., “Effect of Epitalon on telomere length in human cells,” Mech. Ageing Dev., vol. 132, no. 4, pp. 160–164, 2011.
  • V. Khavinson and A. M. Bondarev, “Regulation of telomerase activity by peptides,” Biochemistry (Moscow), vol. 73, no. 11, pp. 1356–1362, 2008.
  • V. Khavinson et al., “Pineal peptides as geroprotectors,” Bull. Exp. Biol. Med., vol. 146, no. 1, pp. 9–12, 2008.
  • V. Khavinson, S. I. Tarnovskaya, N. S. Linkova, et al., “Short cell-penetrating peptides: a model of interactions with gene promoter sites,” Bull. Exp. Biol. Med., vol. 154, no. 3, pp. 403–410, 2013.
  • V. Khavinson, V. Anisimov, and N. Yashin, “Peptide regulation of gene expression and aging,” Adv. Gerontol., vol. 24, no. 2, pp. 193–201, 2011.
  • N. S. Lin’kova, B. I. Kuznik, and V. K. Khavinson, “Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging,” Adv. Gerontol., vol. 25, no. 3, pp. 478–482, 2012.
  • N. I. Chalisova et al., “Short peptides stimulate skin cell regeneration during ageing,” Adv. Gerontol., vol. 27, no. 4, pp. 699–703, 2014.
  • N. S. Lin’kova et al., “Peptide regulation of skin fibroblast functions during their aging in vitro,” Bull. Exp. Biol. Med., vol. 161, no. 1, pp. 175–178, 2016.
  • I. A. Vinogradova et al., “Effect of Ala-Glu-Asp-Gly peptide on life span and spontaneous tumor development in rats,” Bull. Exp. Biol. Med., vol. 144, no. 6, pp. 825–830, 2007.
  • G. Kossoy et al., “Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice,” In Vivo, vol. 20, no. 2, pp. 253–257, 2006.
  • V. N. Anisimov et al., “Inhibitory effect of the peptide epitalon on spontaneous mammary tumors in HER-2/neu transgenic mice,” Int. J. Cancer, vol. 101, no. 1, pp. 7–10, 2002.
  • V. N. Anisimov et al., “Epithalon decelerates aging and suppresses breast adenocarcinoma development in HER-2/neu mice,” Bull. Exp. Biol. Med., vol. 134, no. 2, pp. 187–190, 2002.
  • V. Khavinson et al., “Short peptides regulate gene expression and protein synthesis during aging,” Neuroendocrinol. Lett., vol. 31, no. 3, pp. 319–324, 2010.
  • O. V. Korkushko et al., “Normalizing effect of pineal peptides on melatonin rhythm in aging primates and humans,” Adv. Gerontol., vol. 20, no. 1, pp. 74–85, 2007.
  • V. Khavinson et al., “Pineal-regulating tetrapeptide epitalon improves retinal condition in retinitis pigmentosa,” Neuroendocrinol. Lett., vol. 23, no. 4, pp. 365–368, 2002.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.