Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

GHK-Cu Copper Peptide 50MG

GHK-Cu

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide–copper complex widely studied in biochemical, dermatological, and regenerative research. Originally identified in human plasma, saliva, and urine, GHK-Cu is known for its strong affinity for copper ions and its role in modulating cellular signaling pathways related to tissue remodeling and repair.*

In laboratory research settings, GHK-Cu is utilized as a copper-binding peptide model for investigating peptide–metal interactions, gene expression regulation, extracellular matrix dynamics, and cellular responses involved in skin, connective tissue, and vascular biology. Its small size, well-characterized structure, and biological relevance make it a frequently cited compound in peptide chemistry and molecular biology research.*

  • Peptide Name: GHK-Cu (Copper Peptide)
  • Peptide Class: Tripeptide–copper complex
  • Amino Acid Length: 3 amino acids (GHK) complexed with Cu²⁺
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis and copper chelation with in-house purification
  • Designation: For Research Use Only (RUO)
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Products will arrive in a lyophilized (powder) form for maximum stability.

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GHK-Cu

Scientific & Research Context

GHK-Cu has been extensively referenced in scientific literature for its role in regulating gene expression associated with tissue structure, antioxidant defense, and cellular repair mechanisms.* Research models have explored its influence on fibroblast activity, collagen synthesis pathways, angiogenic signaling, and inflammatory modulation in controlled experimental systems.*

In research environments, GHK-Cu has been used to investigate:*

  • Peptide–metal ion binding and transport mechanisms
  • Gene expression related to extracellular matrix remodeling*
  • Cellular signaling involved in skin and connective tissue biology*
  • Antioxidant and oxidative stress response pathways*
  • Structure–function relationships of bioactive tripeptides*

Its copper-binding capability and endogenous origin make GHK-Cu a valuable reference compound in studies focused on peptide-mediated regulation of cellular homeostasis.*

Quality & Analytical Assurance

Each batch of GHK-Cu undergoes comprehensive analytical testing to confirm peptide sequence accuracy, copper complexation, molecular identity, and purity. Validation through high-performance liquid chromatography (HPLC) and mass spectrometry (MS) ensures consistency, reliability, and reproducibility across research applications.

Storage & Handling

GHK-Cu is supplied as a lyophilized powder to maintain stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established laboratory peptide protocols to preserve molecular integrity and prevent degradation or metal dissociation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Pickart, L., & Margolina, A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” International Journal of Molecular Sciences, 2018; 19(7):1987.
  • Pickart, L. “The human tri-peptide GHK and tissue remodeling.” Journal of Biomaterials Science, Polymer Edition, 2008; 19(8):969–988.
  • Maquart, F. X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J. C., & Borel, J. P. “Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.” FEBS Letters, 1988; 238(2):343–346.
  • Siméon, A., Wegrowski, Y., Bontemps, Y., & Maquart, F. X. “Expression of matrix metalloproteinases and their inhibitors by fibroblasts in response to the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.” Journal of Investigative Dermatology, 2000; 115(6):962–968.
  • Wegrowski, Y., Maquart, F. X., & Borel, J. P. “Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.” Life Sciences, 1992; 51(13):1049–1056.
  • Hostynek, J. J., & Maibach, H. I. “Copper peptides in dermatology.” Clinical Dermatology, 2014; 32(1):109–114.
  • Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. “GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration.” BioMed Research International, 2015; Article ID 648108.
  • Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. “Discovering the link between copper and skin.” Journal of the European Academy of Dermatology and Venereology, 2014; 28(4):403–409.
  • Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. “GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.” BioMed Research International, 2015.
  • Gruchlik, A., Chodurek, E., & Dzierzewicz, Z. “Effect of Gly-His-Lys and its copper complex on TGF-β secretion in normal human dermal fibroblasts.” Acta Poloniae Pharmaceutica, 2014; 71(6):954–958.
  • Wang, X., et al. “GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.” Wound Repair and Regeneration, 2017; 25(2):270–278.
  • Kukowska, M., Kukowska-Kaszuba, M., & Dzierzbicka, K. “In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential candidates for therapeutics in skin and tissue infections.” Bioorganic & Medicinal Chemistry Letters, 2015; 25(3):542–546.
  • Mulder, G. D., et al. “Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper.” Wound Repair and Regeneration, 1994; 2(4):259–269.
  • Canapp, S. O., et al. “The effect of topical tripeptide-copper complex on healing of ischemic open wounds.” Veterinary Surgery, 2003; 32(6):515–523.
  • Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. “The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline.” Brain Sciences, 2017; 7(2).
  • Zhang, H., Wang, Y., & He, Z. “Gly-His-Lys alleviates neuronal apoptosis due to intracerebral hemorrhage via the miR-339-5p/VEGFA pathway.” Frontiers in Neuroscience, 2018; 12:644.
  • Zhou, X.-M., et al. “GHK peptide inhibits bleomycin-induced pulmonary fibrosis in mice by suppressing TGF-β1/Smad-mediated epithelial-to-mesenchymal transition.” Frontiers in Pharmacology, 2017; 8:904.
  • Park, J.-R., Lee, H., Kim, S.-I., & Yang, S.-R. “The tripeptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.” Oncotarget, 2016; 7(36):58405–58417.
  • Sever’yanova, L. A., & Dolgintsev, M. E. “Effects of tripeptide Gly-His-Lys in pain-induced aggressive-defensive behavior in rats.” Bulletin of Experimental Biology and Medicine, 2017; 164(2):140–143.
  • Sever’yanova, L. A., & Plotnikov, D. V. “Binding of glyprolines to L-arginine inverts its analgesic and anti-aggressogenic effects.” Bulletin of Experimental Biology and Medicine, 2018; 165(5):621–624.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.