Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

KP-10 Kisspeptin 5MG

KP-10

KP-10 (Kisspeptin-10) is a synthetic decapeptide derived from the endogenous kisspeptin family of neuropeptides, which are encoded by the KISS1 gene and play a critical role in reproductive endocrinology. As the shortest biologically active fragment of full-length kisspeptin, KP-10 is widely utilized in research settings to study hypothalamic–pituitary–gonadal (HPG) axis regulation and neuroendocrine signaling mechanisms.*

In laboratory and experimental models, KP-10 functions as a potent agonist of the G-protein–coupled receptor GPR54 (also known as KISS1R). Activation of this receptor is known to stimulate gonadotropin-releasing hormone (GnRH) neurons, making KP-10 a valuable tool for investigating hormonal signaling cascades, receptor kinetics, and peptide–receptor interactions under controlled conditions.*

  • Peptide Name: KP-10 (Kisspeptin-10)
  • Peptide Class: Neuropeptide / Kisspeptin analog
  • Amino Acid Length: 10 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing Method: Solid-phase peptide synthesis
  • Designation: For Research Use Only (RUO)
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Products will arrive in a lyophilized (powder) form for maximum stability.

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KP-10

Scientific & Research Context

KP-10 is extensively referenced in scientific literature as a key regulator of reproductive hormone release through its action on kisspeptin receptors expressed in the hypothalamus.* Experimental studies have employed KP-10 to explore:

  • GnRH neuron activation and pulsatility
  • Regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release
  • Kisspeptin receptor signaling pathways (GPR54/KISS1R)
  • Neuroendocrine control of puberty onset and reproductive function
  • Peptide structure–activity relationships within the kisspeptin family

Due to its short amino acid sequence and high receptor affinity, KP-10 is particularly suited for mechanistic and pharmacological studies requiring rapid receptor engagement and reproducible signaling outcomes.*

Quality & Analytical Assurance

Each batch of KP-10 is produced using validated solid-phase peptide synthesis techniques and undergoes rigorous analytical testing to confirm molecular identity, sequence accuracy, and purity. High-performance liquid chromatography (HPLC) and mass spectrometry (MS) are used to ensure batch-to-batch consistency, reliability, and suitability for advanced research applications.

Storage & Handling

KP-10 is supplied as a lyophilized powder to preserve peptide stability during storage and transport. Store unopened vials in a cool, dry location protected from light. Once reconstituted, the peptide should be handled according to standard laboratory peptide protocols to minimize degradation and maintain molecular integrity.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., et al. (2003). The GPR54 gene as a regulator of puberty. New England Journal of Medicine, 349(17), 1614–1627. https://pubmed.ncbi.nlm.nih.gov/14573733/
  • de Roux, N., Genin, E., Carel, J. C., Matsuda, F., Chaussain, J. L., & Milgrom, E. (2003). Hypogonadotropic hypogonadism due to loss of function of the kisspeptin receptor GPR54. Proceedings of the National Academy of Sciences, 100(19), 10972–10976. https://pubmed.ncbi.nlm.nih.gov/12944565/
  • Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J. M., Le Poul, E., et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G-protein-coupled receptor GPR54. Journal of Biological Chemistry, 276(37), 34631–34636. https://pubmed.ncbi.nlm.nih.gov/11457843/
  • Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., et al. (2004). Kisspeptin activation of gonadotropin-releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology, 80(4), 264–272. https://pubmed.ncbi.nlm.nih.gov/15665556/
  • Dhillo, W. S., Chaudhri, O. B., Patterson, M., Thompson, E. L., Murphy, K. G., Badman, M. K., et al. (2005). Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. Journal of Clinical Endocrinology & Metabolism, 90(12), 6609–6615. doi: 10.1210/jc.2005-1468
  • Thompson, E. L., Patterson, M., Murphy, K. G., Smith, K. L., Dhillo, W. S., Todd, J. F., et al. (2004). Central and peripheral administration of kisspeptin-10 stimulates gonadotropin release in rodents. Endocrinology, 145(12), 5512–5519. https://pubmed.ncbi.nlm.nih.gov/15331579/
  • Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009). Kisspeptin signaling in the brain. Endocrine Reviews, 30(6), 713–743. https://pubmed.ncbi.nlm.nih.gov/19770291/
  • Navarro, V. M., Castellano, J. M., Fernández-Fernández, R., Barreiro, M. L., Roa, J., Sánchez-Criado, J. E., et al. (2004). Developmental and hormonally regulated mRNA expression of KiSS-1 and GPR54 in rat hypothalamus. Endocrinology, 145(10), 4565–4574. https://pubmed.ncbi.nlm.nih.gov/15217982/
  • George, J. T., Veldhuis, J. D., Roseweir, A. K., Newton, C. L., Faccenda, E., Millar, R. P., et al. (2011). Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Journal of Clinical Endocrinology & Metabolism, 96(8), E1228–E1236. doi: 10.1210/jc.2011-0089
  • Harter, C. J. L., Kavanagh, G. S., & Smith, J. T. (2018). The role of kisspeptin neurons in reproduction and metabolism. Journal of Endocrinology, 238(3), R173–R183. doi: 10.1530/JOE-18-0108
  • Mead, E. J., Maguire, J. J., Kuc, R. E., & Davenport, A. P. (2007). Kisspeptins: a multifunctional peptide system with roles in reproduction, cancer and the cardiovascular system. British Journal of Pharmacology, 151(8), 1143–1153. doi: 10.1038/sj.bjp.0707295
  • Ly, T., Harihar, S., & Welch, D. R. (2020). KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer and Metastasis Reviews. doi: 10.1007/s10555-020-09868-9
  • Pazarci, P., Korkmaz, M., Korkmaz, E., et al. (2020). The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croatian Medical Journal, 61(1), 55–61.
  • Gibula-Tarlowska, E., & Kotlinska, J. H. (2020). Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in rats. Behavioural Pharmacology, 31(2–3), 272–282. doi: 10.1097/FBP.0000000000000557
  • Comninos, A. N., Demetriou, L., Wall, M. B., Shah, A. J., Clarke, S. A., Narayanaswamy, S., et al. (2017). Kisspeptin modulates sexual and emotional brain processing in humans. Journal of Clinical Investigation, 127(2), 709–719. doi: 10.1172/JCI89519
  • Bhattacharya, M., & Babwah, A. V. (2015). Kisspeptin: Beyond the brain. Endocrinology, 156(4), 1218–1227. doi: 10.1210/en.2014-1915
  • Antitumor efficacy of kisspeptin in human malignant mesothelioma cells. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922395/

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.