Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

KPV

KPV (Ac-KPV-NH₂) is a synthetic tripeptide composed of Lysine-Proline-Valine, corresponding to the C-terminal fragment of the endogenous melanocortin peptide α-melanocyte-stimulating hormone (α-MSH). Due to its defined sequence and compact structure, KPV is widely utilized as a research reagent in controlled laboratory environments for the study of peptide signaling mechanisms and melanocortin-related pathways.*

  • Peptide Sequence: Ac-Lys-Pro-Val-NH₂
  • Peptide Class: Tripeptide
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 10 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Synthesized and quality-controlled in-house
  • Designation: For Research Use Only (RUO)

$74.00

$70.30 each
$66.60 each

Products will arrive in a lyophilized (powder) form for maximum stability.

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KPV

Scientific & Research Context

KPV has been investigated in peer-reviewed in vitro and preclinical studies as a minimal bioactive fragment of α-MSH.* Published literature has reported that KPV is capable of interacting with melanocortin-associated signaling systems and intracellular pathways involved in inflammatory and immune-related cellular processes, including transcriptional regulators such as NF-κB, within experimental models.*

In research settings, KPV has been examined in relation to:*

  • Cellular signaling pathways associated with inflammatory regulation*
  • Intestinal and epithelial barrier model systems*
  • Cytokine expression and immune-cell signaling*
  • Peptide transport, uptake, and receptor-interaction mechanisms*

Due to its small molecular size and sequence specificity, KPV is frequently selected for mechanistic studies where short peptide fragments are required to evaluate structure–function relationships and intracellular signaling responses.*

Quality & Analytical Assurance

Each batch of KPV undergoes rigorous analytical testing to confirm molecular identity, sequence accuracy, and purity using validated HPLC and MS methodologies, ensuring consistency and reproducibility across research applications.

Storage & Handling

Store lyophilized material under appropriate laboratory conditions to maintain stability. Reconstitution and handling should follow standard peptide research protocols.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB Journal, 1989; 3(11): 2282–2284.
  • Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 2008; 14(3): 324–331.
  • Xiao B, et al. Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis. Molecular Therapy, 2017; 25(7): 1628–1640.
  • Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008; 134(1): 166–178.
  • Richards DB, Lipton JM. Effect of alpha-MSH 11–13 (lysine-proline-valine) on fever in the rabbit. Peptides, 1984; 5(4): 815–817.
  • Brzoska T, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo, and future perspectives. Endocrine Reviews, 2008; 29(5): 581–602.
  • Luger TA, Brzoska T. α-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of the Rheumatic Diseases, 2007; 66(Suppl 3): iii52–iii55.
  • Cutuli M, et al. Antimicrobial effects of alpha-MSH peptides. Journal of Leukocyte Biology, 2000; 67(2): 233–239.
  • Masman MF, et al. Synthesis and conformational analysis of peptide analogues with antifungal properties. Bioorganic & Medicinal Chemistry, 2006; 14(22): 7604–7614.
  • de Souza KS, et al. Improved cutaneous wound healing after intraperitoneal injection of alpha-melanocyte-stimulating hormone. Experimental Dermatology, 2015; 24(3): 198–203.
  • Lonati C, et al. Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats. Peptides, 2013; 50: 145–152.
  • Colombo G, et al. Gene expression profiling reveals multiple protective influences of alpha-melanocyte-stimulating hormone in experimental heart transplantation. Journal of Immunology, 2005; 175(5): 3391–3401.
  • Colombo G, et al. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Shock, 2007; 27(3): 326–333.
  • Schiller M, et al. Human dermal fibroblasts express prohormone convertases and produce POMC-derived peptides. Journal of Investigative Dermatology, 2001; 117(2): 227–235.
  • Brzoska T, et al. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore. Advances in Experimental Medicine and Biology, 2010; 681: 107–116.
  • Getting SJ, et al. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) α-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics, 2003; 306(2): 631–637.
  • Pawar K, et al. Transdermal iontophoretic delivery of lysine-proline-valine (KPV) across microporated human skin. Journal of Pharmaceutical Sciences, 2017; 106(7): 1814–1820.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.