Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

MGF IGF-1 EC Mechano Growth Factor 5MG

MGF IGF-1 Ec

MGF IGF-1 Ec, commonly referred to as Mechano Growth Factor (MGF), is a synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 Ec splice variant. This fragment is endogenously expressed in response to mechanical stress, tissue loading, or injury and is widely studied in muscle biology, tissue repair, and cellular adaptation research.*

Unlike full-length IGF-1, the MGF C-terminal peptide represents a localized, short-acting signaling molecule associated with autocrine and paracrine activity rather than systemic endocrine effects. In controlled laboratory settings, MGF C-terminal is used to investigate early-stage signaling events related to mechanical strain, muscle satellite cell activation, and localized regenerative responses.*

  • Peptide Name: MGF IGF-1 Ec (C-Terminal)
  • Alternate Name: Mechano Growth Factor (MGF)
  • Peptide Class: IGF-1 splice variant (E-domain fragment)
  • Amino Acid Length: C-terminal fragment (typically 24 amino acids)
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 5 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)

$80.00

$76.00 each
$72.00 each

Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

MGF IGF-1 Ec

Scientific & Research Context

In published scientific literature, the IGF-1 Ec splice variant and its C-terminal domain have been studied for their role in mechanotransduction and localized growth factor signaling.* Research suggests that MGF differs functionally from systemic IGF-1 by promoting rapid, site-specific cellular responses following mechanical load or tissue disruption.*

Within experimental research models, MGF C-terminal has been utilized to explore:*

  • Satellite cell activation and early myogenic signaling
  • Local tissue responses to mechanical stress
  • Differences between endocrine IGF-1 and autocrine/paracrine IGF-1 splice variants
  • Muscle regeneration and repair pathways in vitro
  • Structure–function relationships of IGF-1 isoforms and fragments

Due to its short biological activity window and localized signaling profile, MGF C-terminal is frequently selected for mechanistic studies requiring precise temporal control rather than prolonged growth factor exposure.*

Quality & Analytical Assurance

Each batch of MGF IGF-1 Ec (C-Terminal) is synthesized using validated solid-phase peptide synthesis protocols and subjected to comprehensive analytical testing. High-performance liquid chromatography (HPLC) and mass spectrometry (MS) are employed to confirm peptide identity, sequence integrity, and purity, ensuring consistency and reproducibility for advanced research applications.

Storage & Handling

MGF IGF-1 Ec (C-Terminal) is supplied as a lyophilized powder to maintain stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow standard laboratory peptide protocols to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Goldspink, G., Yang, S. Y., & Goldspink, D. F. “The role of IGF-I Ec (MGF) in muscle damage and repair.” Exercise and Sport Sciences Reviews, 30(3), 2002, pp. 101–106.
  • Yang, S. Y. et al. “The IGF-I Ec peptide (MGF) is a locally acting growth factor involved in skeletal muscle regeneration.” Journal of Physiology, 522(2), 2000, pp. 273–280.
  • Hill, M. & Goldspink, G. “Expression and splicing of the insulin-like growth factor gene in muscle.” Advances in Experimental Medicine and Biology, 2003.
  • McKoy, G. et al. “Expression of insulin growth factor-1 splice variants and structural genes in response to muscle damage.” Journal of Physiology, 516(2), 1999, pp. 583–592.
  • Matheny, R. W. et al. “Mechano-growth factor (MGF) and muscle growth.” American Journal of Physiology – Endocrinology and Metabolism, 292(3), 2007, E909–E918.
  • Goldspink, G. “Mechanical signals, IGF-I gene splicing, and muscle adaptation.” Physiology, 20, 2005, pp. 232–238.
  • Barton-Davis, E. R. et al. “IGF-1 splice variants and muscle regeneration.” Proceedings of the National Academy of Sciences (PNAS), 95(26), 1998, pp. 15603–15607.
  • Philippou, A. et al. “Role of IGF-1 isoforms in skeletal muscle physiology.” Growth Hormone & IGF Research, 17(6), 2007, pp. 471–480.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.