Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

NAD+ Nicotinamide Adenine Dinucleotide Biofermented 1000MG

NAD+ Biofermented

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme essential to cellular energy metabolism and redox reactions across all living organisms. This biofermented NAD+ is produced through a controlled microbial fermentation process designed to yield a highly purified, research-grade compound suitable for advanced biochemical and molecular biology studies.*

In laboratory research, NAD+ is widely utilized to investigate mitochondrial function, cellular respiration, oxidative stress responses, and enzymatic pathways involved in metabolic regulation. Due to its central role in electron transfer reactions, NAD+ serves as a critical cofactor in studies involving glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation.*

  • Compound Name: Nicotinamide Adenine Dinucleotide (NAD+)
  • Production Method: Biofermentation
  • Molecular Class: Pyridine nucleotide coenzyme
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 100 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Fermentation-derived with downstream purification
  • Designation: For Research Use Only (RUO)

$225.00

$213.75 each
$202.50 each

Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

NAD+ Biofermented

Scientific & Research Context

NAD+ plays a foundational role in cellular metabolism as a redox cofactor cycling between oxidized (NAD⁺) and reduced (NADH) states. In experimental models, NAD+ is used to study energy homeostasis, mitochondrial efficiency, and the regulation of metabolic enzymes such as dehydrogenases.*

Additionally, NAD+ functions as a substrate for several enzyme families, including sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38-related enzymes, making it a valuable research tool for exploring cellular stress responses, DNA repair mechanisms, and signaling pathways linked to metabolic adaptation.*

Within controlled laboratory settings, NAD+ has been utilized to investigate:*

  • Cellular respiration and ATP production*
  • Redox balance and oxidative stress pathways*
  • Mitochondrial function and metabolic flux*
  • Enzyme-dependent NAD+ consumption pathways*
  • Comparative studies of metabolic cofactor dynamics*

Its universal presence in living systems and well-characterized biochemical behavior make NAD+ a cornerstone molecule in metabolic and cellular research.*

Quality & Analytical Assurance

Each batch of biofermented NAD+ undergoes rigorous quality control testing to confirm molecular identity, structural integrity, and purity. Verification by high-performance liquid chromatography (HPLC) and mass spectrometry (MS) ensures consistency, reproducibility, and suitability for research applications.

The biofermentation process provides a controlled and scalable method of production, followed by purification steps designed to remove residual impurities and ensure a high-quality research compound.

Storage & Handling

NAD+ is supplied as a lyophilized powder to maximize stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstituted material should be handled according to standard laboratory protocols for nucleotide cofactors to preserve chemical stability and experimental reliability.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Ying, W., “NAD⁺/NADH and NADP⁺/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences,” Antioxidants & Redox Signaling, vol. 10, no. 2, pp. 179–206, 2008.
  • Verdin, E., “NAD⁺ in aging, metabolism, and neurodegeneration,” Science, vol. 350, no. 6265, pp. 1208–1213, 2015.
  • Canto, C., Menzies, K. J., and Auwerx, J., “NAD⁺ Metabolism and the Control of Energy Homeostasis,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 76, pp. 115–125, 2011.
  • Belenky, P., Bogan, K. L., and Brenner, C., “NAD⁺ metabolism in health and disease,” Trends in Biochemical Sciences, vol. 32, no. 1, pp. 12–19, 2007.
  • Pollak, N., Dölle, C., and Ziegler, M., “The power to reduce: pyridine nucleotides—small molecules with a multitude of functions,” Biochemical Journal, vol. 402, no. 2, pp. 205–218, 2007.
  • Sauve, A. A., “NAD⁺ and vitamin B3: from metabolism to therapies,” Journal of Pharmacology and Experimental Therapeutics, vol. 324, no. 3, pp. 883–893, 2008.
  • Imai, S., and Guarente, L., “NAD⁺ and sirtuins in aging and disease,” Trends in Cell Biology, vol. 24, no. 8, pp. 464–471, 2014.
  • Chini, C. C. S., Tarragó, M. G., and Chini, E. N., “NAD and the aging process: Role in life, death and everything in between,” Molecular and Cellular Endocrinology, vol. 455, pp. 62–74, 2017.
  • “NAD⁺ Science 101 – What Is NAD⁺ & Why It’s Important,” Elysium Health.
  • “Nicotinamide Riboside: Benefits, Side Effects and Dosage,” Healthline.
  • Matthews, R. T., Yang, L., Browne, S., Baik, M., and Beal, M. F., “Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects,” Proceedings of the National Academy of Sciences USA, vol. 95, no. 15, pp. 8892–8897, 1998.
  • “What You Need to Know About Resveratrol Supplements,” WebMD.
  • Sun, N., Youle, R. J., and Finkel, T., “The Mitochondrial Basis of Aging,” Molecular Cell, vol. 61, no. 5, pp. 654–666, 2016.
  • Stipp, D., “Beyond Resveratrol: The Anti-Aging NAD Fad,” Scientific American Blog Network.
  • Gomes, A. P., et al., “Declining NAD⁺ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging,” Cell, vol. 155, no. 7, pp. 1624–1638, 2013.
  • Mendelsohn, A. R., and Larrick, J. W., “Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels,” Rejuvenation Research, vol. 17, no. 1, pp. 62–69, 2014.
  • Kang, C., Chung, E., Diffee, G., and Ji, L. L., “Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α,” Experimental Gerontology, vol. 48, no. 11, pp. 1343–1350, 2013.
  • Ringholm, S., et al., “Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice,” Experimental Gerontology, vol. 48, no. 11, pp. 1311–1318, 2013.
  • Lloret, A., and Beal, M. F., “PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions,” Neurochemical Research, 2019.
  • Shan, C., et al., “Protective effects of β-nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson’s disease,” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 94, 2019.
  • Maddison, D. C., and Giorgini, F., “The kynurenine pathway and neurodegenerative disease,” Seminars in Cell & Developmental Biology, vol. 40, pp. 134–141, 2015.
  • Garten, A., et al., “Physiological and pathophysiological roles of NAMPT and NAD metabolism,” Nature Reviews Endocrinology, vol. 11, no. 9, pp. 535–546, 2015.
  • Yamaguchi, S., and Yoshino, J., “Adipose Tissue NAD⁺ Biology in Obesity and Insulin Resistance,” BioEssays, vol. 39, no. 5, 2017.
  • Humiston, J. E., “Nicotinamide Adenine Dinucleotide,” FDA document.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.