Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Mitochondrial Peptide_10MG

MOTs-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a synthetic analog of a naturally occurring mitochondrial-derived peptide encoded within mitochondrial DNA. Unlike classical nuclear-encoded peptides, MOTS-c originates from the mitochondrial genome and has been studied as a signaling molecule involved in cellular energy regulation, metabolic stress responses, and mitochondrial–nuclear communication in experimental research models.*

In scientific literature, MOTS-c is recognized as part of a novel class of mitochondrial peptides that function as metabolic signaling factors, making it a valuable research compound for investigating mitochondrial biology, metabolic homeostasis, and cellular adaptation pathways under stress conditions.*

  • Peptide Name: MOTS-c
  • Peptide Class: Mitochondrial-derived signaling peptide
  • Amino Acid Length: 16 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 10 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)

$65.00

$61.75 each
$58.50 each

Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

MOTs-C

Scientific & Research Context

MOTS-c has been examined in published research for its role in regulating metabolic signaling pathways, including interactions with AMPK activation, insulin sensitivity pathways, and mitochondrial stress signaling in cellular and animal models.* Studies have explored MOTS-c as a mediator of mitochondrial–nuclear crosstalk, particularly in the context of metabolic challenge, exercise-mimetic signaling, and cellular resilience mechanisms.*

In controlled laboratory environments, MOTS-c has been utilized to investigate:*

  • Mitochondrial-derived peptide signaling and bioenergetics*

  • Cellular responses to metabolic and oxidative stress*

  • AMPK-associated metabolic regulation pathways*

  • Mitochondrial–nuclear communication mechanisms*

  • Adaptive gene expression responses to energetic demand*

Its short sequence, unique mitochondrial origin, and reproducible synthetic profile make MOTS-c a valuable tool in mitochondrial research, metabolic biology, and peptide signaling studies.*

Quality & Analytical Assurance

Each batch of MOTS-c is synthesized under strict quality control standards and undergoes comprehensive analytical verification. High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) are used to confirm molecular identity, sequence accuracy, and ≥99% purity, ensuring consistency and reliability across research applications.

Storage & Handling

MOTS-c is supplied in lyophilized form to enhance long-term stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established peptide research best practices to maintain molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015; 21(3): 443–454.
  • Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 2018; 28(3): 516–524.e7.
  • Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radical Biology & Medicine, 2016; 100: 182–187.
  • Zarse K, Ristow M. A mitochondrially encoded hormone ameliorates obesity and insulin resistance. Cell Metabolism, 2015; 21(3): 355–356.
  • Reynolds JC, Lai RW, Woodhead JST, et al. Mitochondrial-derived peptides protect against metabolic disease. Trends in Endocrinology & Metabolism, 2021; 32(5): 382–395.
  • Lee C. Mitochondrial peptides: novel regulators of metabolism. Trends in Endocrinology & Metabolism, 2018; 29(7): 454–465.
  • Cobb LJ, Lee C, Xiao J, et al. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of metabolism and longevity. Aging Cell, 2016; 15(6): 1134–1144.
  • Merry TL, Chan A, Woodhead JST, et al. Mitochondrial-derived peptides in energy metabolism. American Journal of Physiology – Endocrinology and Metabolism, 2020; 319(4): E659–E666.
  • Barazzoni R, Short KR, Nair KS. Effects of mitochondrial-derived peptides on metabolic signaling pathways. Journal of Clinical Endocrinology & Metabolism, 2019; 104(3): 771–778.
  • Miller B, Kim SJ, Kumagai H, et al. Exercise-induced regulation of mitochondrial-derived peptides. FASEB Journal, 2020; 34(1): 768–779.
  • Lu H, Wang L, Chen Q, et al. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. Journal of Molecular Medicine, 2019; 97(4): 473–485.
  • Kim SJ, Kim KH, Son JM, et al. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological Reports, 2019; 7(13): e14171.
  • Crescenzo R, Bianco F, Mazzoli A, et al. A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance. European Journal of Nutrition, 2016; 55(1): 1–6.
  • Cataldo LR, Fernández-Verdejo R, Santos JL, Galgani JE. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not obese individuals. Journal of Investigative Medicine, 2018; 66(6): 1019–1022.
  • Che N, Yang J, Liu Z, et al. MOTS-c improves osteoporosis by promoting type I collagen synthesis in osteoblasts via TGF-β/SMAD signaling. European Review for Medical and Pharmacological Sciences, 2019; 23(8): 3183–3189.
  • Hu BT, Chen WZ. MOTS-c promotes osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. European Review for Medical and Pharmacological Sciences, 2018; 22(21): 7156–7163.
  • Fuku N, Pareja-Galeano H, Zempo H, et al. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell, 2015.
  • Qin Q, Delrio S, Wan J, et al. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. International Journal of Cardiology, 2018; 254: 23–27.
  • Yang Y, Gao X, Zhang M, et al. The role of mitochondria-derived peptides in cardiovascular disease. Biomedicine & Pharmacotherapy, 2019; 117: 109075.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.