Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

PNC-28_20MG

PNC-28

PNC-28 is a synthetic peptide derived from the N-terminal region of the human tumor suppressor protein p53, engineered for use as a research tool in molecular biology and oncology-focused investigations. In published scientific studies, PNC-28 has been examined for its cell membrane–associated interactions and structure–function relationships in controlled experimental models.*

As a p53-related peptide fragment, PNC-28 is frequently referenced in research exploring tumor suppressor signaling, membrane biology, and peptide–lipid interactions, offering investigators a defined molecular probe distinct from full-length p53 protein constructs.*

  • Peptide Name: PNC-28
  • Peptide Class: p53-derived synthetic peptide
  • Amino Acid Length: 28 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: As specified per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)

$200.00

$190.00 each
$180.00 each

Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

PNC-28

Scientific & Research Context

PNC-28 has been investigated in scientific literature as part of broader research into p53 functional domains, peptide–membrane interactions, and selective cellular binding mechanisms in experimental systems.* Unlike gene-based or full-protein approaches, short p53-derived peptides such as PNC-28 allow researchers to isolate and study domain-specific behavior under tightly controlled laboratory conditions.*

In research environments, PNC-28 has been utilized to explore:*

  • Structure–function relationships of p53-derived peptide domains*
  • Peptide interactions with cellular membranes and lipid components*
  • Molecular mechanisms associated with tumor suppressor–related signaling*
  • Comparative studies between native p53 protein and peptide analogs*
  • Cell biology models examining peptide localization and binding dynamics*

Its defined sequence and reproducible synthesis make PNC-28 a valuable compound in oncology research, membrane biology, and peptide chemistry studies.*

Quality & Analytical Assurance

Each batch of PNC-28 undergoes rigorous analytical testing to confirm molecular identity, sequence accuracy, and purity. Verification through validated HPLC and MS methodologies ensures batch-to-batch consistency, reliability, and reproducibility for research applications.

Storage & Handling

PNC-28 is supplied in lyophilized form to enhance stability during storage and shipping. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established peptide research and laboratory best practices to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Soussi T. The p53 tumor suppressor gene: from molecular biology to clinical investigation. Annals of the New York Academy of Sciences, 2000; 910: 121–137.
  • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell, 1997; 88(3): 323–331.
  • Hupp TR, Lane DP, Ball KL. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochemical Journal, 2000; 352(Pt 1): 1–17.
  • Aylon Y, Oren M. Living with p53, dying of p53. Cell, 2007; 130(4): 597–600.
  • Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature, 2009; 458(7242): 1127–1130.
  • Resnick-Silverman L, et al. p53 as a transcriptional regulator: regulation of cell fate. Oncogene, 1998; 17(25): 3295–3305.
  • Marchenko ND, Moll UM. Mitochondrial death functions of p53. Molecular & Cellular Oncology, 2014; 1(1): e955995.
  • Li Y, et al. Membrane-associated p53 interactions and apoptosis signaling. Journal of Biological Chemistry, 2003; 278(48): 47806–47812.
  • Chipuk JE, Green DR. Dissecting p53-dependent apoptosis. Cell Death & Differentiation, 2006; 13(6): 994–1002.
  • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000; 408(6810): 307–310.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.