Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Semax_40MG

Semax

Semax is a synthetic heptapeptide analog derived from a fragment of adrenocorticotropic hormone (ACTH 4–10), engineered to retain neuroactive properties while eliminating hormonal activity associated with full-length ACTH. In scientific research, Semax is widely utilized as a neuropeptide research tool for investigating central nervous system signaling, neurotrophic factor modulation, and peptide-mediated cellular communication in controlled experimental models.*

Due to its enhanced stability and resistance to enzymatic degradation compared to native ACTH fragments, Semax is frequently referenced in neuroscience, neurochemistry, and molecular biology research as a reproducible compound for studying peptide–receptor interactions and intracellular signaling pathways.*

  • Peptide Name: Semax
  • Peptide Class: ACTH-derived synthetic neuropeptide analog
  • Amino Acid Length: 7 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 30 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)

$60.00

$57.00 each
$54.00 each

Products will arrive in a lyophilized (powder) form for maximum stability.

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Semax

Scientific & Research Context

Semax has been examined in published research for its role in neurotrophic signaling pathways, including studies exploring modulation of brain-derived neurotrophic factor (BDNF) expression, synaptic plasticity mechanisms, and neuronal survival signaling in experimental systems.* Research models have also investigated Semax in the context of cognitive processes, stress-response signaling, and neurovascular regulation, without endocrine activation.*

In laboratory research environments, Semax has been utilized to investigate:*

  • Neuropeptide-mediated signaling in the central nervous system*

  • Modulation of neurotrophic factor expression and gene regulation*

  • Synaptic plasticity and neuronal communication pathways*

  • Peptide effects on cerebral blood flow and neurovascular signaling*

  • Structure–function relationships of ACTH-derived peptide fragments*

Its short sequence, chemical stability, and well-characterized structure make Semax a valuable compound in neuroscience research, peptide chemistry, and molecular signaling studies.*

Quality & Analytical Assurance

Each batch of Semax undergoes rigorous analytical testing to confirm molecular identity, sequence accuracy, and purity. Verification through validated HPLC and MS methodologies ensures batch-to-batch consistency, reliability, and reproducibility across research applications.

Storage & Handling

Semax is supplied in lyophilized form to enhance stability during storage and shipping. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established peptide research and laboratory best practices to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Ashmarin IP, et al. Semax is a novel neuropeptide with neuroprotective and nootropic properties. Neuroscience and Behavioral Physiology, 1997; 27(5): 555–560.
  • Ashmarin IP, Nezavibat’ko VN, et al. Neurochemical mechanisms of the action of the regulatory peptide Semax. Neuroscience and Behavioral Physiology, 2001; 31(2): 123–132.
  • Gusev EI, et al. The neuroprotective effects of Semax in experimental models of cerebral ischemia. Bulletin of Experimental Biology and Medicine, 2003; 136(6): 565–568.
  • Myasoedov NF, et al. Semax and its analogs: molecular mechanisms of neurotropic effects. Neurochemical Journal, 2011; 5(4): 267–274.
  • Stvolinsky SL, et al. Effects of Semax on gene expression of neurotrophins and their receptors in the rat brain. Neuroscience Letters, 2010; 472(2): 129–133.
  • Andreeva LA, et al. Influence of Semax on brain-derived neurotrophic factor (BDNF) expression under experimental cerebral ischemia. Bulletin of Experimental Biology and Medicine, 2006; 142(6): 671–674.
  • Myasoedov NF, Grivennikov IA. Regulatory peptides of the ACTH family and their role in brain plasticity. Russian Journal of Physiology, 2002; 88(8): 1001–1012.
  • Nezavibat’ko VN, et al. Semax effects on monoaminergic neurotransmitter systems in experimental models. Neuroscience and Behavioral Physiology, 1998; 28(4): 424–429.
  • Kozlovskiy SA, et al. Semax modulation of cerebral blood flow and neurovascular regulation in experimental models. Bulletin of Experimental Biology and Medicine, 2005; 140(1): 90–93.
  • Myasoedov NF, et al. Peptide regulation of cognitive functions: experimental studies with Semax. Neurochemical Journal, 2015; 9(3): 176–183.
  • Lebedeva IS, et al. Effects of Semax on the default mode network of the brain. Bulletin of Experimental Biology and Medicine, 2018; 165(5): 653–656.
  • Mars RB, Neubert F-X, Noonan MP, Sallet J, Toni I, Rushworth MFS. On the relationship between the default mode network and the social brain. Frontiers in Human Neuroscience, 2012; 6.
  • Medvedeva EV, et al. The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics, 2014; 15: 228.
  • Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN. The efficacy of Semax in the treatment of patients at different stages of ischemic stroke. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 2018; 118(3-2): 61–68.
  • Agapova TI, et al. Effect of Semax on the temporal dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex. Molecular Genetics, Microbiology and Virology, 2008; (3): 28–32.
  • Scantlebury MH, Chun K-C, Ma S-C, Rho JM, Kim DY. Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice. Neuroscience Letters, 2017; 645: 14–18.
  • Deltheil T, et al. Behavioral and serotonergic consequences of decreasing or increasing hippocampal brain-derived neurotrophic factor protein levels in mice. Neuropharmacology, 2008; 55(6): 1006–1014.
  • Ivanov A, Bobyntsev I, Shepeleva O, Kryukov A, Andreeva L, Myasoedov N. Influence of ACTH(4-7)-PGP (Semax) on the morphofunctional state of hepatocytes under chronic emotional and painful stress. Bulletin of Experimental Biology and Medicine, 2017; 163.
  • Bobyntsev I, Kryukov A, Shepeleva O, Ivanov A. Effects of ACTH-4-7-PGP peptide on lipid peroxidation in liver and serum transaminase activity under acute and chronic immobilization stress. Bulletin of Experimental Biology and Medicine, 2015; 78: 18–21.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.