Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Thymosin Beta-4_5MG

TB-500

TB-500 is a synthetic peptide modeled after an active region of thymosin beta-4 (Tβ4), a naturally occurring intracellular peptide involved in actin regulation and cellular motility. In scientific research, TB-500 is utilized as a peptide research tool for investigating cytoskeletal dynamics, cell migration, tissue remodeling pathways, and peptide-mediated cellular signaling in controlled experimental models.*

Unlike full-length thymosin beta-4, TB-500 is engineered to retain functional domains of interest while offering enhanced stability and consistency for laboratory use. It is frequently referenced in molecular biology, cell biology, and regenerative research literature as a reproducible compound for studying peptide–actin interactions and downstream signaling mechanisms.*

  • Peptide Name: TB-500
  • Peptide Class: Thymosin beta-4–derived synthetic peptide fragment
  • Amino Acid Length: Short synthetic peptide (Tβ4-derived region)
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)
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Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

TB-500

Scientific & Research Context

TB-500 has been examined in published research for its role in actin sequestration, cytoskeletal remodeling, and cellular migration processes, particularly in experimental models evaluating tissue repair signaling, angiogenic pathways, and wound-healing–associated cellular behaviors.* Research literature has explored thymosin beta-4–related peptides in the context of cell motility, inflammation-associated signaling, and extracellular matrix interactions.*

In laboratory research environments, TB-500 has been utilized to investigate:*

  • Actin dynamics and cytoskeletal organization*

  • Cell migration and adhesion signaling pathways*

  • Angiogenic and tissue remodeling mechanisms*

  • Peptide-mediated regulation of inflammatory signaling*

  • Structure–function relationships of thymosin beta-4–derived peptides*

Its defined sequence, chemical stability, and well-characterized biochemical behavior make TB-500 a valuable compound in peptide chemistry, cellular biology, and regenerative research models.*

Quality & Analytical Assurance

Each batch of TB-500 undergoes rigorous analytical testing to confirm molecular identity, sequence integrity, and purity. Verification using validated HPLC and MS methodologies ensures batch-to-batch consistency, reproducibility, and reliability for research applications.

Storage & Handling

TB-500 is supplied in lyophilized form to enhance stability during storage and transport. Store unopened vials in a cool, dry environment protected from light. Reconstitution and handling should follow established peptide research and laboratory best practices to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421–429.
  • Huff T, Müller CS, Otto AM, Netzker R, Hannappel E. β-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001;33(3):205–220.
  • Smart N, Risebro CA, Melville AA, et al. Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177–182.
  • Bock-Marquette I, Saxena A, White MD, et al. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and cardiac repair. Nature. 2004;432(7016):466–472.
  • Sosne G, Chan CC, Thai K, et al. Thymosin β4 promotes corneal wound healing and modulates inflammatory responses following injury. Invest Ophthalmol Vis Sci. 2001;42(13):3005–3014.
  • Malinda KM, Goldstein AL, Kleinman HK. Thymosin β4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 1997;11(6):474–481.
  • Philp D, Goldstein AL, Kleinman HK. Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004;125(2):113–115.
  • Sanders MC, Goldstein AL, Wang YL. Thymosin β4 is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A. 1992;89(10):4678–4682.
  • Hannappel E, Huff T. The thymosins: structure and function. Vitam Horm. 2003;66:257–296.
  • Cheng P, Kuang F, Zhang H, Ju G, Wang J. Beneficial effects of thymosin β4 on spinal cord injury in the rat. Neuropharmacology. 2014;85:408–416.
  • Chopp M, Zhang ZG. Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases. Expert Opin Biol Ther. 2015;15(Suppl 1):S9–S12.
  • Li H, Wang Y, Hu X, Ma B, Zhang H. Thymosin β4 attenuates oxidative stress-induced injury of neural stem/progenitor cells via TLR4/MyD88. Gene. 2019;707:136–142.
  • Dubé KN, Smart N. Thymosin β4 and the vasculature: roles in development, repair, and disease protection. Expert Opin Biol Ther. 2018;18(Suppl 1):131–139.
  • Philp D, St-Surin S, Cha HJ, et al. Thymosin β4 induces hair growth via stem cell migration and differentiation. Ann N Y Acad Sci. 2007;1112:95–103.
  • Carion TW, et al. Thymosin β4 and ciprofloxacin adjunctive therapy improves Pseudomonas keratitis. Cells. 2018;7(10).
  • Kassem KM, Vaid S, Peng H, et al. Tβ4–Ac-SDKP pathway and relevance to the cardiovascular system. Can J Physiol Pharmacol. 2019.
  • Shaghiera AD, Widiyanti P, Yusuf H. Injectable collagen–chitosan–thymosin β4 hydrogels for myocardial infarction research. J Funct Biomater. 2018;9(2).
  • Han HJ, Kim S, Kwon J. Thymosin β4-induced autophagy and cholinergic signaling in neuronal models. Neurotox Res. 2018.
  • Song R, Choi H, Yang HI, et al. Association between serum thymosin β4 levels and disease activity in rheumatoid arthritis. Clin Rheumatol. 2012;31:1253–1258.
  • Sosne G, Qiu P, Christopherson PL, Wheater M. Thymosin β4 suppression of NF-κB signaling following injury. Exp Eye Res. 2007;84(4):663–669.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.