Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Thymosin Alpha 1_10MG

TA-1

TA-1, also known as Thymosin Alpha-1, is a synthetic 28-amino-acid peptide originally isolated from thymic tissue and recognized as a key thymic regulatory peptide in scientific literature. In research settings, TA-1 is widely utilized as a thymic peptide research tool for investigating immune-related signaling pathways, peptide-mediated cellular communication, and thymus-associated regulatory mechanisms in controlled experimental models.*

Due to its well-defined structure and extensive documentation in immunology and molecular biology research, TA-1 serves as a reproducible compound for studying peptide–receptor interactions, intracellular signaling cascades, and gene expression pathways associated with thymic peptides.*

  • Peptide Name: Thymosin Alpha-1 (TA-1)
  • Peptide Class: Thymic regulatory peptide
  • Amino Acid Length: 28 amino acids
  • Form: Lyophilized powder
  • Purity: ≥99% (HPLC verified)
  • Quantity: 3 mg per vial
  • Analytical Verification: HPLC and Mass Spectrometry (MS)
  • Manufacturing: Solid-phase peptide synthesis with in-house purification
  • Designation: For Research Use Only (RUO)

$115.00

Products will arrive in a lyophilized (powder) form for maximum stability.

Free domestic shipping on orders over $300

TA-1

Scientific & Research Context

TA-1 has been extensively referenced in published scientific literature as a thymic peptide involved in immune system signaling and cellular regulation.* Research models have explored its role in T-cell maturation pathways, immune-associated gene expression, and peptide-driven modulation of innate and adaptive immune signaling mechanisms.*

In laboratory research environments, TA-1 has been utilized to investigate:*

  • Thymic peptide signaling and immune cell communication*
  • Regulation of T-cell differentiation and maturation pathways*
  • Peptide-mediated modulation of cytokine signaling networks*
  • Intracellular signaling cascades associated with thymic peptides*
  • Structure–function relationships of thymus-derived peptides*

Its defined amino acid sequence, stability in lyophilized form, and strong presence in peer-reviewed research make TA-1 a valuable compound for immunology research, peptide biology, and molecular signaling studies.*

Quality & Analytical Assurance

Each batch of TA-1 is synthesized and purified under strict quality control standards. Analytical verification via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) confirms molecular identity, sequence accuracy, and purity. This ensures batch-to-batch consistency, reliability, and reproducibility across research applications.

Storage & Handling

TA-1 is supplied in lyophilized form to enhance stability during storage and shipping. Unopened vials should be stored in a cool, dry environment protected from light. Reconstitution and handling should follow established peptide research and laboratory best practices to preserve molecular integrity and minimize degradation.

For further information on proper storage techniques, click the button…

Storage Instructions

Referenced Scientific Literature
Provided for informational and educational purposes only

  • King R, Tuthill C. Immune modulation with thymosin alpha-1 treatment. Vitam Horm. 2016;102:151–178.
  • Zhang C, Zhou J, Cai K, Zhang W, Liao C, Wang C. Gene cloning, expression and immune adjuvant properties of the recombinant fusion peptide Tα1-BLP on avian influenza inactivated virus vaccine. Microb Pathog. 2018;120:147–154.
  • Pei F, Guan X, Wu J. Thymosin alpha-1 treatment for patients with sepsis. Expert Opin Biol Ther. 2018;18(sup1):71–76.
  • Wang G, et al. Immunopotentiator thymosin alpha-1 promotes neurogenesis and cognition in the developing mouse via a systemic Th1 bias. Neurosci Bull. 2017;33(6):675–684.
  • Romani L, et al. Thymosin α1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling. Blood. 2004;103(11):4232–4239.
  • Romani L, et al. Thymosin alpha-1: an endogenous regulator of inflammation, immunity, and tolerance. Ann N Y Acad Sci. 2007;1112:326–338.
  • Goldstein AL, Goldstein AL. From lab to bedside: emerging clinical applications of thymosin alpha-1. Expert Opin Biol Ther. 2009;9(5):593–608.
  • Matteucci C, et al. Thymosin alpha-1 and HIV-1: recent advances and future perspectives. Future Microbiol. 2017;12:141–155.
  • Matteucci C, et al. Thymosin α1 potentiates the release by CD8⁺ cells of soluble factors able to inhibit HIV-1 and HTLV-1 infection in vitro. Expert Opin Biol Ther. 2015;15(Suppl 1):S83–S100.
  • Kharazmi-Khorassani J, Asoodeh A, Tanzadehpanah H. Antioxidant and ACE-inhibitory activity of thymosin alpha-1 peptide. Bioorg Chem. 2019;87:743–752.
  • Kharazmi-Khorassani J, Asoodeh A. Thymosin alpha-1 inhibits cellular proliferation, migration, ROS production, and promotes antioxidant enzyme activity in A549 cells. Environ Toxicol. 2019.
  • Maio M, et al. Large randomized study of thymosin alpha-1, interferon alfa, or both in combination with dacarbazine in metastatic melanoma. J Clin Oncol. 2010;28(10):1780–1787.
  • Danielli R, Fonsatti E, Calabrò L, Di Giacomo AM, Maio M. Thymosin α1 in melanoma: from clinical trials to daily practice. Ann N Y Acad Sci. 2012;1270:8–12.
  • Shen X, et al. Generation of a long-acting thymosin alpha-1-Fc fusion protein and its efficacy in breast cancer inhibition in vivo. Biomed Pharmacother. 2018;108:610–617.
  • Wang F, Yu T, Zheng H, Lao X. Thymosin Alpha-1-Fc modulates immune responses and suppresses melanoma and breast cancer progression. Sci Rep. 2018;8:12351.
  • Xu Y, et al. Thymosin Alpha-1 inhibits CFA-induced pain and microglia-mediated pro-inflammatory cytokine production. Neurosci Bull. 2019.
  • Romani L, et al. Thymosin α1 represents a potential single-molecule-based therapy for cystic fibrosis. Nat Med. 2017;23(5):590–600.
  • Day PF, Duggal M, Nazzal H. Interventions for treating traumatised permanent front teeth: avulsed and replanted. Cochrane Database Syst Rev. 2019;2:CD006542.
  • Schmidt M, et al. Design of a substrate-tailored peptiligase variant for efficient synthesis of thymosin-α1. Org Biomol Chem. 2018;16(4):609–618.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.